Age‐related increases in microsomal quercetin glucuronidation in rat small intestine.

Microsomal quercetin glucuronidation in rat small intestine depends on age and segment.

UDP-glucuronosyltransferase (UGT) activity toward the flavonoid quercetin and UGT protein were characterized in three equidistant small intestine (SI) segments from 4-, 12-, 18-, and 28-month-old male Fischer 344 rats (n = 8/age) using villin to control for enterocyte content. SI microsomal intrinsic clearance of quercetin was increased 3- to 9-fold from 4 months in the proximal and distal SI a...

quercetin glucuronidation in rat small intestine depends on age and segment

fi - Glucosidase Activity in the Rat Small Intestine toward Quercetin

with the quercetin monoglucosides, quercetin-3-O-fi-Dglucopyranoside (Q3G), quercetin-4'-O-fi-D-glucopyranoside (Q4'G) and quercetin-7-O:t7-D-glucopyranoside (Q7G), as well as with quercetin-3-O-rutinoside (rutin) and pnitrophenyl-ll-D-gl"cepyranoside (NPG) by using the HPLC technique. Enzymes were prepared from rat small intestinal mucosa of the duodenum, jejunum and ilellm, among which the en...

Histomorphometric changes of small intestine in pregnant rat

Food intake of rats increases during pregnancy. This requires changes in the structure of the small intestine to absorb additional food. The aim of the present study was to investigate the morphological changes in the layers of small intestine in rats during pregnancy. Duodenum, jejunum and ileum of 18 pregnant Sprague-Dawley rats (day 7, 14 and 21 of pregnancy) were collected. Villous height a...

Bisphenol A glucuronidation and absorption in rat intestine.

Bisphenol A, an environmental estrogen, can be leached from plastic tableware and from the coating of food and drink cans, orally exposing human beings to the compound. The present study focuses on the absorption and metabolism of bisphenol A in the rat intestine, as elucidated experimentally by segmented everted intestine. One hour after the application of 2 micromol of bisphenol A to the muco...